Tolerance Induction after Organ Transplantation, “Delayed Tolerance,” Via the Mixed Chimerism Approach: Planting Flowers in a Battle Field
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Tolerance induction after organ transplantation, “delayed tolerance,” via the mixed chimerism approach
Addendum to: Yamada Y, Boskovic S, Aoyama A, Murakami T, Putheti P, Smith RN, et al. Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates. Am J Transplant 2012; 12:330–40; PMID: 22053723; http://dx.doi.org/10.1111/j.1600-6143. 2011.03795.x We have previously reported that peri-transplant conditioning leads to successful induction of renal allograft toleranc...
متن کاملPreclinical and clinical studies on the induction of renal allograft tolerance through transient mixed chimerism.
PURPOSE OF REVIEW The present review updates the current status of research for induction of tolerance through a mixed chimerism approach in nonhuman primates and humans. RECENT FINDINGS Allograft tolerance has been successfully achieved with a nonmyeloablative conditioning regimen and donor bone marrow transplantation in human leukocyte antigen (HLA)-matched and mismatched kidney transplanta...
متن کاملTolerance Induction Strategies in Vascularized Composite Allotransplantation: Mixed Chimerism and Novel Developments
Since the start of the clinical vascularized composite allotransplantation (VCA) era over a decade ago this field has witnessed significant developments in both basic and translational research. Transplant tolerance, defined as rejection-free acceptance of transplanted organs or tissues without long-term immunosuppression, holds the potential to revolutionize the field of VCA by removing the ne...
متن کاملMinor Antigen Disparities Impede Induction of Long Lasting Chimerism and Tolerance through Bone Marrow Transplantation with Costimulation Blockade
The routine induction of tolerance in organ transplant recipients remains an unattained goal. The creation of a state of mixed chimerism through allogeneic bone marrow transplantation leads to robust donor-specific tolerance in several experimental models and this approach has several features making it attractive for clinical development. One of its major drawbacks, however, has been the toxic...
متن کاملThe Applications of Bone Marrow-Derived Stem Cells to Induce Tolerance and Chimerism in Organ Transplantation
Progress in understanding the cellular and molecular biology of the immune system, in the second half of the 20(th) century brings the transplantation of replacement organs and tissues in clinical reality to cure disease. Immunosuppressive agents that are part of nearly every transplantation procedure, are toxic to some extent and their chronic use predisposes the patient to the development of ...
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تاریخ انتشار 2012